Warp: a method for neural network interpretability applied to gene expression profiles
نویسندگان
چکیده
We show a proof of principle for warping, a method to interpret the inner working of neural networks in the context of gene expression analysis. Warping is an efficient way to gain insight to the inner workings of neural nets and make them more interpretable. We demonstrate the ability of warping to recover meaningful information for a given class on a samplespecific individual basis. We found warping works well in both linearly and nonlinearly separable datasets. These encouraging results show that warping has a potential to be the answer to neural networks interpretability in computational biology.
منابع مشابه
Multivariate Feature Extraction for Prediction of Future Gene Expression Profile
Introduction: The features of a cell can be extracted from its gene expression profile. If the gene expression profiles of future descendant cells are predicted, the features of the future cells are also predicted. The objective of this study was to design an artificial neural network to predict gene expression profiles of descendant cells that will be generated by division/differentiation of h...
متن کاملMultivariate Feature Extraction for Prediction of Future Gene Expression Profile
Introduction: The features of a cell can be extracted from its gene expression profile. If the gene expression profiles of future descendant cells are predicted, the features of the future cells are also predicted. The objective of this study was to design an artificial neural network to predict gene expression profiles of descendant cells that will be generated by division/differentiation of h...
متن کاملPrediction of Blasting Cost in Limestone Mines Using Gene Expression Programming Model and Artificial Neural Networks
The use of blasting cost (BC) prediction to achieve optimal fragmentation is necessary in order to control the adverse consequences of blasting such as fly rock, ground vibration, and air blast in open-pit mines. In this research work, BC is predicted through collecting 146 blasting data from six limestone mines in Iran using the artificial neural networks (ANNs), gene expression programming (G...
متن کاملNetwork-Based Biomarker Discovery: Development of Prognostic Biomarkers for Personalized Medicine by Integrating Data and Prior Knowledge
Advances in genome science and technology offer a deeper understanding of biology while at the same time improving the practice of medicine. The expression profiling of some diseases, such as cancer, allows for identifying marker genes, which could be able to diagnose a disease or predict future disease outcomes. Marker genes (biomarkers) are selected by scoring how well their expression levels...
متن کاملInvestigation of Histone Lysine-Specific Demethylase 5D (KDM5D) Isoform Expression in Prostate Cancer Cell Lines: a System Approach
Background: It is now well-demonstrated that histone demethylases play an important role in developmental controls, cell-fate decisions, and a variety of diseases such as cancer. Lysine-specific demethylase 5D (KDM5D) is a male-specific histone demethylase that specifically demethylates di- and tri-methyl H3K4 at the start site of active genes. In this light, the aim of this study was to invest...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- CoRR
دوره abs/1708.04988 شماره
صفحات -
تاریخ انتشار 2017